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Tirzepatide (Mounjaro, Zepbound) Strengths: Highest efficacy for both glucose control and weight loss Dual mechanism (GLP-1 + GIP) may provide unique benefits Once-weekly dosing Generally well-tolerated Considerations: Higher cost than semaglutide Less long-term safety data (newer medication) Cardiovascular outcome trial not yet complete (though expected to be positive) Best for: Patients prioritizing maximum weight loss

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Preexisting health conditions Conditions like diabetes, gastrointestinal issues, or B12 deficiency may require dosage modifications for safety and effectiveness

doi: 10.1038/s41467-020-14309-w 24 IshibashiYMatsuiTTakeuchiMYamagishiS