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Molecular imaging studies of A in LLD compared to controls have shown either no significant differences, less A or greater A in a more limited neuroanatomical distribution (temporal and parietal cortices) compared to LLD with MCI, MCI or AD [329,330,331,332,333]

Moreover, Glp1r Tie2/ mice do not display differences in renal artery or kidney Glp1r expression, as opposed to Glp1r VSM/ mice in which Glp1r expression is markedly reduced in these structures, further highlighting that VSMCs are the main renal GLP-1Rexpressing cell type