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However, under some circumstances, oxalate may bind to minerals and form crystals that can lead to the formation of kidney stones ( Consuming too much vitamin C has the potential to increase the amount of oxalate in your urine, thus increasing your risk of developing kidney stones ( In one study, when adults took a 1,000-mg vitamin C supplement twice daily for 6 days, the amount of oxalate they excreted increased by 20% ( High vitamin C intake is not only associated with greater amounts of urinary oxalate but also linked to the development of kidney stones, especially if you consume more than 2,000 mg per day ( Instances of kidney failure have also been reported in people who have taken more than 2,000 mg in a day

Whether pairing these approaches with GLP-1RA therapy improves glycemic or weight outcomes remains unknown and should be tested in well-designed clinical trials

Li Y, Zhang X, Wang Z, Li B, Zhu H

Without them, deficiency can occur