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Long-term data show sustained benefits for both therapies, and clinicians typically base treatment selection on patient factors such as comorbidities , tolerance , cost , and individual preferences regarding injection schedules and side-effect management

For constipation contributing to bloating, osmotic laxatives such as polyethylene glycol may be helpful, but consult your healthcare provider before use

3 Future direction Current and forthcoming research on GLP-1 RAs in pediatric obesity will focus on new agents, optimal dosing regimens, long-term outcomes, and comprehensive safety monitoring