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The difference often comes down to how the compound is delivered and how much of it your body can actually use

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GHK-Cus documented NGF stimulation appears to sit within its broader gene expression modulation signature rather than representing a direct receptor interaction, which is mechanistically coherent with the transcriptomic reactivation data showing GHK-Cu shifting aging gene expression profiles toward younger patterns (PMID: 25904764)

Investigative Ophthalmology & Visual Science, 49 (11), 51515160