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For progressive forms, such as secondary progressive MS (SPMS) and primary progressive MS (PPMS), therapeutic options are limited compared to relapsingremitting MS (RRMS) [141]

We know for every drug thats been approved going through the safety profile, the toxicology, the pharmokinetics that has then been approved in humans, theres just as many, if not more, that have fallen by the wayside along the way because they dont have a specific benefit for whatever it was we were looking to treat, he said

That means: Hypokalemia can develop or worsen which can lead to: Cardiac arrhythmias Muscle weakness QT prolongation In severe cases, sudden cardiovascular instability This is a classic board-style pearl that many clinicians forget because B12 feels benign. But in profoundly deficient patientsespecially those with severe megaloblastic anemiarepletion is metabolically active treatment