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The UniProt Consortium (2019) UniProt: a worldwide hub of protein knowledge

In addition to 2D cell culture, 3D organoid systems or co-culture systems with stromal fibroblasts, immune cells or endothelial cells have increased translational relevance by modelling the tumour microenvironment, heterotypic signalling and drug penetration kinetics (219, 220)

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This map provides a kind of blueprint, showing how key parts of the heartlike the pacemaker system, heart valves, and the wall between the upper chambersform and function, says Enik Lzr, co-lead author of the study