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doi:10.2174/157015909787602788 Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, ONeil GN, BG-12 Phase IIb Study Investigators (2008) Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

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After oral administration, the majority of curcumin is excreted as metabolites, with only a small fraction entering the bloodstream, at concentrations well below those required to inhibit most of its anti-inflammatory targets