A2: In vitro studies suggest that Epithalon can activate telomerase in certain cell types and support telomere maintenance, making it a useful tool compound for exploring how telomere biology relates to genomic stability and cellular aging mechanisms
A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-
Jomova K., Alomar S.Y., Alwasel S.H., Nepovimova E., Kuca K., Valko M
Research Square Print2022 Nov 29