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Access this article Similar content being viewed by others Abbreviations AD: Alzheimer disease ADR: Adverse drug reactions Apo: Apolipoprotein ASCVD: Atherosclerotic cardiovascular disease AUC: Area under the curve CAC: Coronary artery calcium CAR: Constitutive androstane receptor CD36: Scavenger receptor Class B2 CETP: Cholesteryl ester transfer protein CK: Creatine kinase CoQ10: Ubiquinone CPIC: Clinical Pharmacogenetics Implementation Consortium CVD: Cardiovascular disease eNOS: Endothelial nitric oxide synthase ER: Estrogen receptor GPX: Glutathione peroxidase HC: Hypercholesterolemia FH: Familial hypercholesterolemia HDL: High-density lipoprotein HL: Hepatic lipase HMGR: 3-Hydroxy-3-methylglutaryl-CoA reductase GRS: Genetic risk score LCAT: Lecithin:cholesterol acyltransferase LDL: Low-density lipoprotein LDLR: LDL receptor MACE: Major atherosclerotic cardiovascular events MTHFR: Methylenetetrahydrofolate reductase MYLIP: Myosin regulatory light chain interacting protein PCSK9: Proprotein convertase subtilisin/kexin type 9 PD: Pharmacodynamics PK: Pharmacokinetics PON1: Paraoxonase 1 PPAR: Peroxisome proliferator-activated receptor PXR: Pregnane X receptor RXR: Retinoid X receptor alpha SAMS: Statin-associated muscle symptoms SCAP: SREBP cleavage-activating protein Se: Selenium SNVs: Single nucleotide variations SOD2: Manganese-dependent superoxide dismutase SRAE: Statin-related adverse events SR-B1: Scavenger receptor class B1 SREBP: Sterol regulatory element-binding proteins VLDL: Very low-density lipoprotein References Gencer B, Marston NA, Im K, Cannon CP, Sever P, Keech A, et al

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In summary, Se deficiency appears to be a risk factor for HT and the current evidence does not justify the use of Se supplementation as part of the treatment of HT, despite its ability to improve immune function

Research demonstrates that AOD-9604 upregulates beta-3 adrenergic receptors in fat cells, promoting energy expenditure and fat oxidation through mechanisms distinct from traditional stimulants or full growth hormone