The distinction is not minor
Importantly, AhR/ARNT transcriptional activities are dependent upon the conformational structure of the bound receptor which is suggested to be directly influenced by ligand binding ( In addition to AhR, EDCs are also able to mediate their actions through nuclear receptor subfamily 1, group I, member 2 (NR1I2), also known as the steroid and xenobiotic receptor (SXR)
However, because cuproptosis is a relatively recently defined cell death modality, the extent to which this mechanism operates across diverse physiological and pathological contexts remains to be fully established
The activities of major ROS-detoxifying enzymes, i.e., glutathione peroxidase (GP), glutathione reductase (GR), catalase, and the level of glutathione in the liver were determined