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Indeed, in the case of the peroxiredoxin Mt AhpE, the reactivity of the persulfidated protein was higher than that of the thiol protein in the case of a non-specific electrophile, but lower in the case of the specific hydroperoxide substrates ( The higher acidity of LMW persulfides versus thiols could lead one to think that, in the case of a protein, a negative charge would appear upon persulfidation

It separates the nucleus from the cytosol and changes in its selective permeability mediate leakage of caspases and other pro-apoptotic factors into the nucleus

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