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DPP-IV is the enzyme that destroys GLP-1 within 2 minutes of its release inhibiting it means your natural GLP-1 works longer

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When to seek medical advice : Patients should contact their GP or prescribing clinician if nausea is severe and persistent, if they are unable to keep down fluids for more than 24 hours, if they experience severe abdominal pain, or if side effects significantly impact their quality of life