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This participant was already taking tirzepatide when she enrolled in the trial, but before any stimulation was delivered, giving us a unique opportunity to make foundational observations about how the drug alters brain signals. Short term suppression, long-term questions After the electrodes were implanted and Participant 3 reached her full dose of tirzepatide, she reported no food preoccupation and her related NAc activity was silent

PMID: 32 SandurSKPandeyMKSungBAhnKSMurakamiASethiGet al

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[DOI] [PubMed] [Google Scholar] Panaro MA, Corrado A, Benameur T, Paolo CF, Cici D, Porro C