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doi:10.1038/s42003-025-07738-0

Conclusions BBB breakdown significantly impacts the development and progression of neurodegenerative diseases, and unraveling the cellular and molecular mechanisms underlying BBB dysfunction is vital to elucidate how neural computations are sustained under pathological conditions and to devise therapeutic approaches

However, research into transdermal patches combined with penetration enhancers or microneedle arrays is exploring whether sustained peripheral delivery can achieve sufficient systemic levels to produce CNS effects for highly potent compounds