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The most reliable and cost-effective way to ensure adequate iodine intake for the general population is to use iodized salt, a common table salt enriched with iodine (30 mg for each kg of salt in Italy)

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Conduct phase I/II clinical trials with rigorous pharmacokinetic/pharmacodynamic (PK/PD) monitoring, using validated biomarkers to ensure target engagement (e.g., reduced urinary 4-HNE levels) and safety (e.g., no iron deficiency)