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This innovation will increase the therapeutic potential of mAbs in CVD, where multiple signaling pathways need to be modulated

Cells were then loaded for 30 min with 2 mol/l Fluo-4AM (cell-permeant formulation, Thermofisher) in Lockes buffer consisted of 154 mmol/l NaCl, 4 mmol/l NaHCO 3 , 5 mmol/l KCl, 2,3 mmol/l CaCl 2 , 1 mmol/l MgCl 2 , 5 mmol/l glucose, 10 mmol/l Hepes

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This suggests that nutrient-induced GLP-1 secretion was inhibited by pasireotide via SSTR-Gi-dependent inhibition of cAMP levels