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The important role of pathogens in AD is not a new theory and was first proposed by the Czech physician Oskar Fischer in 1907 (Allnutt and Jacobson, 2020), and was also one of the observations made by the Italian physician Francesco Bonfiglio in 1908, who noted the similarities with manifestations of neurosyphilis ( Treponema Pallidum ) and AD after comparison of brain samples sent to him by Alois Alzheimer (Miklossy, 2015)

Introduction Vitamin B12, or cobalamin, is a water-soluble vitamin, that plays an essential role in cellular metabolism, particularly in DNA synthesis, methylation processes, and mitochondrial functions (Green et al., 2017)

Much of the glutathione is destroyed by stomach acid or enzymes in the small intestine

Carty CL, Heagerty P, Heckbert SR, Jarvik GP, Lange LA, Cushman M, Tracy RP, Reiner AP