The ROC curves were generated for each enzyme individually, and a combined analysis using a multivariable logistic regression model was performed to assess the overall predictive value of these markers
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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)
The BNF and product information advise monitoring potassium levels in patients with severe deficiency during initial treatment