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Saxenda vs Newer GLP-1 Drugs Compared to semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro): Saxenda uses liraglutide , an earlier GLP-1 compound requires daily dosing produces similar GI effects, but with continuous exposure still carries risk of severe motility disorders and organ injury Although sometimes perceived as less aggressive, Saxenda is not risk-free