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Putative mechanisms of tirzepatide-mediated nephroprotection The pathogenesis of CKD in patients with T2D likely involves other potential contributors besides hyperglycemia, such as hypertension, dyslipidemia, obesity, insulin resistance, glomerular atherosclerosis, renal ischemia, and nephron aging [53]

In obesity management, liraglutide, semaglutide, and tirzepatide significantly reduce body mass and ameliorate cardiovascular and metabolic risk factors

doi: 10.1038/s41598-020-80894-x

These benefits are thought to arise from multiple mechanisms, including improvements in endothelial function, inhibition of vascular inflammation, and enhanced myocardial metabolism via cAMP/PKA and AMPK pathways