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After the release of NO, it immediately spreads into the cavernous body and vascular smooth muscle cells, inducing the activation of soluble guanylate cyclase and the accumulation of cyclic guanosine phosphate (cGMP), promoting the relaxation of vascular and cavernous smooth muscle by reducing intracellular Ga2+, and increasing blood flow and intracavernous pressure, resulting in penile erection (Burnett and Musicki 2005)

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The limited efficacy of current antidepressant therapies can be explained by the heterogeneity of depressive disorders

The effect of the combination was superior across multiple indices, including a reduction in dizziness-related functional deficits by 2.3-fold compared with betahistine alone