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Furthermore, GLP-1R/glucagon receptor dual agonists are being investigated for the treatment of NAFLD ( The pathogenesis of non-alcoholic fatty liver disease The first phase of NAFLD is characterized by accumulation of fat in the liver (hepatic steatosis), which may progressively lead to NASH (in 520% of patients) with or without concomitant fibrosis

Currently, dietary modifications, along with agents such as acarbose, diazoxide, and somatostatin analogs, continue to represent the standard management approach despite challenges related to tolerability, adherence, and variable efficacy