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When partially digested food sits in the fundus longer than normal, mechanoreceptors and chemoreceptors send distension and acidity signals to the area postrema and nucleus tractus solitarius in the brainstem

As the plaques grow over time, they can protrude into the arterial lumen, narrowing the vessel and potentially obstructing blood flow (100)

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We are also indebted to Andrea Panozo, Bishnu Pahari, Karen Courville, Patricia Espindola, Silvia Prandini, Veruscka Lecchi, and Svitlana Yakymchuk for care of the study participants