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Summary: Yes, vitamin B12 is a water-soluble vitamin that dissolves in water and is excreted through urine, though uniquely it can be stored in the liver for several years

GCLC polymorphism has been shown to be associated with decreased GCLC expression in a patient with hemolytic anemia (Beutler et al., 1999), GSH levels and drug resistance among tumor cell lines (Walsh et al., 2001), decreased GCL activity and GSH levels in patients with schizophrenia (Gysin et al., 2007)