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The rest of the groups in descending order of action were as follows: XJZ-A, XJZ-C, Pos, and XJZ-P (Figure 1e)

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Indeed, transgenic mice given the human presenilin-1 (PS1) genewhich encodes one of the two subunits of -secretasewith one missense mutation (Val97Leu, PS1V97L) formed abundant A oligomers (Zhang et al., 2014), produced cognitive deficits, and exhibited cellular oxidative stress markers (Tian et al., 2019

Fully stained cells were then washed three times with PBS in the dark, mounted onto glass coverslips (Fisher Scientific, 125442) with ProLong Gold antifade mounting media (Thermo Fisher Scientific, P10144), and dried overnight in the dark