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NNMT inhibition by 5-Amino-1MQ preserves the cellular nicotinamide pool important for NAD+ biosynthesis and conserves the methyl-donor pool by reducing SAM consumption

From its origins in structure-guided drug design to its current applications across multiple research disciplines, 5-amino-1MQ exemplifies how targeted enzyme inhibition can provide insights into complex biological systems while maintaining the specificity required for rigorous scientific investigation