Patients were split roughly in half ad were given either weekly injections of semaglutide or a placebo
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La investigacin se orient entonces a derivados de la florizina25, obtenindose compuestos con potente selectividad, mayor estabilidad, biodisponibilidad y con adecuada tolerancia dando origen a este nuevo grupo de frmacos inhibidores selectivos de SGLT2 (iSLGT2)
Specific metabolic changes observed during GLP-1 treatment include: Improved insulin sensitivity , allowing cells to use glucose more efficiently Reduced hepatic glucose production , contributing to better glycaemic control Changes in body composition , with loss of both fat mass and some lean tissue Alterations in lipid metabolism , often resulting in improved cholesterol profiles Body composition studies suggest that lean tissue loss typically accounts for approximately 20-30% of total weight lost during GLP-1 therapy, though this varies considerably between individuals and depends on concurrent physical activity and protein intake
