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Semaglutide is well-suited for patients combining weight loss with hormone replacement because it has the longest clinical safety record and minimal interactions with other medications

At TrimBody M.D., we combine tapering with extra methods such as: Small-dose support injections

A 2025 systematic review and meta-analysis in eClinicalMedicine (Tzang et al., 18 RCTs, 3,771 participants) found that adults with obesity who stopped GLP-1 receptor agonists regained an average of 5.63 kg, with HbA1c rising 0.25 percentage points and waist circumference, BMI, systolic blood pressure, and fasting glucose all deteriorating

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