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Observations also indicated a potential decrease in markers of oxidative stress and matrix metalloproteinases (MMPs), which degrade extracellular matrix proteins

79 The promising benefits observed in major cardiovascular trials have sparked interest in their potential application for HF, particularly in patients with comorbid T2D or metabolic syndrome

In the ATTAIN-1 Phase 3 trial, the most frequently reported adverse events with orforglipron 36 mg versus placebo were nausea (33.7% vs 10.4%), constipation (25.4% vs 9.3%), diarrhea (23.1% vs 9.6%), and vomiting (24.0% vs 4.0%)

In earlier trials, about 70% of patients experienced at least one mild adverse effect similar to those seen with other vaccines, including injection site pain, rash, headaches, muscle soreness, and fevers