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383,384 Dotinurad, a selective urate reabsorption inhibitor available in Japan, inhibits URAT1 with high selectivity, demonstrating non-inferiority to febuxostat in lowering serum UA levels with no significant safety concerns 385 (Table 4)

By focusing on tumor nitrogen metabolism features, it reveals the specificity and diversity of nitrogen metabolism within the tumor microenvironment, identifies potential therapeutic strategies targeting these characteristics, and suggests new directions for cancer treatment

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JCI Insight (2018) 3(8)