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Additional mechanistic studies demonstrated that both dihexa and Nle 1 -AngIV, its parent compound, were effective stimulators of hippocampal synaptogenesis, thus providing a rational explanation for their procognitive activities

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Although they share a high degree of homology, the physiologic roles of these hormones are unique, governed by differences in expression pattern, biopotency, and regulation with LH serving as a key regulator of gonadal steroidogenesis and ovulation, and hCG predominantly active in pregnancy and fetal development