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Diet and Helicobacter pylori infection
In VRK2-high tumors, VRK2 promotes SLC7A11 trafficking from the ER to the Golgi, enhancing GSH synthesis and conferring resistance to GSH inhibition
It not only interacts with tight junction proteins in epithelial cells to maintain the integrity of the physical barrier but also regulates DCs, neutrophils, macrophages, and the differentiation of T lymphocyte subgroups, thereby inhibiting the release of proinflammatory cytokines and chemokines to achieve immune regulation (120)
And glutathione deficiency may contribute to severe COVID-19 infection
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