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The conjugation increases the amphipathic nature of the bile acids making them much less toxic as well as more easily secreted into the bile canaliculi

4 Approved to reduce the risk of major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors

The peptide reaches peak plasma concentration while endogenous nicotinamide levels are at their circadian low point, which occurs in the early morning hours before food intake

GLP-1 stimulates insulin secretion