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In addition to its effect on glucose homeostasis, glucagon has lipolytic and thermogenic actions in liver and adipose tissue which contribute to its weight-lowering effects [20]

There should be an inflection point in the size of the market once oral versions are available and the government Medicare / Medicaid programs start to cover the drugs for weight loss (this requires legislation to be passed, the timing of which is uncertain)

GLP-1 therapies influence pathways tied to addiction and reward, according to the Endocrine Society A randomized clinical trial published in JAMA Psychiatry found semaglutide reduced alcohol cravings and consumption Users commonly report: Reduced desire to drink Feeling full faster when drinking Less reward from alcohol The data: early, but directionally consistent While long-term industry sales data is still developing, the early signals from clinical studies, observational research, and population polling all point in the same direction: GLP-1 use is associated with lower alcohol consumption for at least some users

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