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In parallel, iron-handling disturbances (such as labile iron accumulation and ferritinophagy-mediated iron release) initiate a pre-ferroptotic state, lowering the threshold for ferroptotic execution upon inflammatory or mechanical insults (13,14)

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(2) Microglia phagocytose myelin debris, which is important as myelin debris can inhibit OPC differentiation, while efficient clearance of myelin debris allows for effective remyelination after experimental demyelination in rodents (Kotter, 2006

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