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In particular, topiramate may control the flow of glutamate and cysteine through System Xc-, which could impact GSH synthesis and improve the ability of GPX4 to change harmful lipid hydroperoxides into safe lipid alcohols

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Document the session details in the patient record, including total volume infused, any adverse reactions, and the patient's subjective response

The velocity of such a ping-pong reaction with infinite true k cat and K m values can be described by the equation [ E ]/ V = 1 /[GSSCys]+ 2 /[GSH], wherein the Dalziel coefficients 1 and 2 are the slopes of secondary plots for k cat app (GSH) and k cat app (GSSCys) , respectively 39 (Supplementary Table 1)