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Heroin metabolism After 21 days of differentiation, 50 organoids per well were loaded in triplicate into a 96-well plate and treated with culture media with 10 M heroin for 1, 3, 6, and 24 hours

A total of 41% of the study volunteers had nausea, which varied in severity: Mild: 21% Moderate: 3% Severe: 15% Further, about 56% of the study volunteers complained of stretching and yawning, which also varied in severity: Mild: 36% Moderate: 13% Severe: 8% Other recorded side effects included in this review were flushing, increased or decreased appetite, and drowsiness

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