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Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12

Recommending B12 Supplements The choice of supplementation depends on the severity and underlying cause of the deficiency (1,4)

Current evidence grade : based on GRADE criteria, amino acid metabolites merit Low to Moderate quality evidence: consistent associations and mechanistic plausibility are offset by predominant cross-sectional designs, high confounding risk, and lack of interventional validation

Vitamin D Vitamin D is a fat-soluble steroid hormone that is essential for the human body