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Anecdotal reports have suggested that the use of glucagon-like peptide 1 receptor agonists (GLP-1 RA) might be associated with a rare cause of sudden blindness called non-arteritic anterior ischemic optic neuropathy (NAION)

An alternative and complementary hypothesis proposes that the depletion of GSH in the nucleus may also result from age-related impairments in the lens microcirculation system, which fails to deliver sufficient GSH and other antioxidants to the inner nucleus [14,18]

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Early trials in the 2000s did not show meaningful weight loss versus placebo, and it never received FDA approval for that use