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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

Integration with EV proteomics continued to reveal overlaps between pseudotime-associated genes and EV signals, with 24 and 10 overlapping genes in Trajectory A and 18 and 8 for Trajectory B for the before-L-serine- and the after-L-serine-treatment groups, respectively (Supplementary Fig

In dermatology, glutathione has gained popularity for its role in skin brightening and whitening treatments

Redox signaling involved in nutrient-sensing mechanisms The nutrient-sensing network is integral to how cells perceive and respond to their nutritional environment, directly impacting pathologic processes