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In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling

Importance of Neurotransmitters for Cognitive Health Role of Acetylcholine in Memory and Learning Acetylcholine, one of the most important neurotransmitters, directly impacts your memory and learning abilities