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Researchers consulting recent reviews (PMID 41966639) should attend to the regulatory framing as much as the mechanism framing

In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

This causes the skin to develop pigmentation, tanning, signs of dullness or ageing, and uneven tone

[39] Nestor, J