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NAION, A Rare but Serious Optic Nerve Risk One of the most discussed ocular concerns linked to GLP-1 therapy is non-arteritic anterior ischemic optic neuropathy, or NAION, sometimes described as an eye stroke. NAION occurs when blood flow to the optic nerve is suddenly reduced, causing painless but often permanent vision loss in one eye

The active-site cavity, which is located between the two domains, comprises a glutathione binding site (G-site), formed mainly by the N-terminal domain, and a hydrophobic substrate-binding site (H-site), which is formed by the C-terminal domain

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