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Description

Because it targets three hormone pathways simultaneously, Retatrutide has become one of the most closely watched medications in metabolic health research

10.1038/mp.2012.141 23 HarastaA

Eli Lilly is targeting an FDA submission in late 2026

Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants