tirzepatide new england journal of medicine 60-Second Club: The SUMMIT trial examined cardiovascular outcomes treatment with in patients with heart failure with preserved ejection fraction and obesity. Read the full trial Tirzepatide Once Weekly in Children

If we extend this observation to adult neurogenesis, promoter hypermethylation might not be responsible for the final repression of intrinsic fate-determination TFs, which occurs in later stages of neuronal development (Figure 1)

No multiplicity adjustments were made in assessing secondary parameters

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SURMOUNT-OSA: Tirzepatide and obstructive sleep apnea The SURMOUNT-OSA trial (Malhotra et al., NEJM 2024, NEJMoa2404881, PMID 38912654) evaluated tirzepatide in adults with moderate to severe obstructive sleep apnea and obesity, in two parallel populations: subjects not receiving continuous positive airway pressure (CPAP) and subjects receiving CPAP at baseline