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In contrast, the 81 genes that were higher expressed in the carriage strain 710 comprised, among the others, genes involved in inorganic ion transport and metabolism and genes encoding two sigma factors ( rpoD and rpoE ), the tuf genes for the elongation factor Tu, clpX (encoding the Clp protease), a tpsA gene, and 14 genes encoding ribosomal proteins

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The study included 517 patients with PCOS who ceased metformin treatment upon confirmation of pregnancy, with a recorded birth defect rate of 0.6%