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Given the activation of receptors as the only direct action of a neurotransmitter, beta-endorphin is a relatively well-known example of a peptide neurotransmitter primary transmitter at a synapse having highly specific interactions with opioid receptors in the central nervous system [34,35]

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Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia: Study protocol for a randomized controlled trial (SALSA trial)

No human efficacy trials have been published, so it remains an investigational research compound