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Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids

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Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]