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While pancreatic cell plasticity offers promising avenues for restoring -cell mass in diabetes through reprogramming of endogenous cells or transplantation of induced -cells generated in vitro , the efficiency and applicability of these processes in humans remain under active investigation

MC4R, appetite and sexual function MC4R is the main regulator of energy balance in the hypothalamus (particularly in the PVN, paraventricular nucleus)

This can lead to dehydration, fatigue and headaches